The No. 9 Oklahoma Sooners earned their eighth win in their past nine games Saturday at Iowa State.
It was also Lon Kruger's first win at Hilton Coliseum in his 10 seasons coaching OU.
Oklahoma (14-5, 9-4) maintains second place in the Big 12 behind league-leading Baylor. Iowa State (2-16, 0-13) remained winless in conference play.
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