Skip to main contentSkip to main content
You have permission to edit this article.
Edit
In honor of Independence Day, Tulsa World is providing unlimited access to all of our content from June 28th-July 4th! Presented by Grigsby's Carpet Tile & Hardwood
AP

Challenge Study Shows Efficacy of RSV Vaccine in Healthy Adults

  • Updated
  • 0
Challenge Study Shows Efficacy of RSV Vaccine in Healthy Adults

THURSDAY, June 23, 2022 (HealthDay News) -- For healthy adults, the bivalent prefusion F respiratory syncytial virus (RSVpreF) vaccine is effective against symptomatic RSV infection and viral shedding, according to a study published in the June 23 issue of the New England Journal of Medicine.

Beate Schmoele-Thoma, M.D., from Pfizer Pharma in Berlin, and colleagues conducted a phase 2a study involving healthy adults aged 18 to 50 years who were randomly assigned to receive a single intramuscular injection of either the RSVpreF vaccine or placebo. Participants were inoculated intranasally with the RSV A Memphis 37b challenge virus at about 28 days after injection and were observed for 12 days.

The researchers found that for symptomatic RSV infection confirmed by any detectable viral RNA on at least two consecutive days, the vaccine efficacy was 86.7 percent after inoculation with the challenge virus. The median area under the curve for the RSV viral load as measured by reverse transcriptase-quantitative polymerase chain-reaction in nasal wash samples was 0.0 and 96.7 hours×log10 copies per milliliter in the vaccine and placebo groups, respectively. At 28 days after injection, the geometric mean factor increase from baseline in RSV A-neutralizing titers was 20.5 and 1.1 in the vaccine and placebo groups, respectively. Compared with the placebo group, the vaccine group had more local injection-site pain. Neither group had serious adverse events.

"Whether the vaccine will be able to prevent lower respiratory tract disease in persons at higher risk for RSV-associated serious illness has yet to be determined," writes the author of an accompanying editorial.

All the authors were employed by biopharmaceutical companies, including Pfizer, which funded the study.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

0 Comments

Originally published on consumer.healthday.com, part of the TownNews Content Exchange.

Build your health & fitness knowledge

* I understand and agree that registration on or use of this site constitutes agreement to its user agreement and privacy policy.

Related to this story

Most Popular

Police fired tear gas from the windows of the Arizona Capitol building to disperse hundreds of people demonstrating outside Friday night, as lawmakers briefly huddled in a basement. The lawmakers were working to complete their 2022 session as thousands of protesters gathered on the Capitol grounds in Phoenix. They were divided into groups condemning and supporting the Supreme Court’s Roe v. Wade decision. KPHO-TV reported the officers opened fire when several anti-abortion protesters started banging on glass doors of the building. It wasn’t immediately known if there were injuries or arrests.

Gun deaths in Oklahoma have increased since a “permitless carry” law allowing people over the age of 21 to carry a gun without a permit or training went into effect in 2019, according to a newspaper’s review of data. The Oklahoman analyzed state medical examiner data. It found that Oklahoma has recorded some of its deadliest months in history since the law took effect. In the decade before “permitless carry,” only 10 months had 70 or more firearm deaths. From November 2019 until January, there were 10 months with more than 70 gun-related deaths. Following recent mass shootings in Buffalo, New York, Uvalde, Texas, and in Tulsa, Republican leaders in Oklahoma haven't shown interest in any gun control measures.

The Supreme Court has ruled that Americans have a right to carry firearms in public for self-defense, a major expansion of gun rights. The court struck down a New York gun law in a ruling expected to directly impact half a dozen other populous states. Thursday's decision came with recent mass shootings fresh in the nation’s mind and Americans emotionally divided on the issue. Across the street from the court, the Senate sped toward passage of its own national legislation, a gun law modest in scope but still the most far-reaching in decades.  Justice Clarence Thomas wrote for the high court's 6-3 conservative majority.

As the World Health Organization convenes its emergency committee to consider if the spiraling outbreak of monkeypox warrants being declared a global emergency, some experts say WHO’s decision to act only after the disease spilled into the West could entrench the inequities that arose between rich and poor countries during the coronavirus pandemic. Many scientists also doubt any declaration would help to curb the epidemic, since the developed countries recording the most recent cases are already moving to shut it down. Monkeypox has sickened people for decades in central and west Africa. To date, no deaths have been seen outside Africa. The WHO said Thursday it did not expect to announce any decisions by its emergency committee before Friday.

The Supreme Court has stripped away women’s constitutional protections for abortion. It's a fundamental and deeply personal change for Americans' lives after nearly a half-century under the court's landmark Roe v. Wade decision. Friday's new ruling is likely to lead to abortion bans in roughly half the states. The ruling by the high court's conservative majority was unthinkable just a few years ago. It was the culmination of decades of efforts by abortion opponents, made possible by an emboldened right side of the court that has been fortified by three appointees of former President Donald Trump. The ruling came more than a month after the stunning leak of a draft opinion by Justice Samuel Alito.

Dear Dr. Blonz: Attempting to cut back on carbs, I bought some "sugar-free" candy with maltitol as its primary ingredient. The Nutrition Facts information lists sugars as 0 grams per serving, but shows carbohydrates as 25 grams! Is maltitol just another form of sugar?

Listen now and subscribe: Apple Podcasts | Google Podcasts | Spotify | RSS Feed | Omny Studio

Get up-to-the-minute news sent straight to your device.

Topics

Breaking News

News Alert